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Resminostat hydrochloride
CAS No. 1187075-34-8
Resminostat hydrochloride ( RAS2410 hydrochloride;4SC-201 hydrochloride )
产品货号. M10639 CAS No. 1187075-34-8
A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥697 | 有现货 |
|
| 10MG | ￥1337 | 有现货 |
|
| 25MG | ￥2633 | 有现货 |
|
| 50MG | ￥4682 | 有现货 |
|
| 100MG | ￥6747 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Resminostat hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).
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产品描述A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM); decreases levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21; downregulates phosphorylation of 4E-BP1 and p70S6k.Liver Cancer Phase 2 Clinical
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同义词RAS2410 hydrochloride;4SC-201 hydrochloride
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC1;HDAC3;HDAC6;HDAC8
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研究领域Cancer
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适应症Liver Cancer
化学信息
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CAS Number1187075-34-8
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分子量385.87
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分子式C16H20ClN3O4S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 50 mg/mL
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SMILESO=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1.[H]Cl
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化学全称2-Propenamide, 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-, hydrochloride (1:1), (2E)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mandl-Weber S, et al. Br J Haematol. 2010 May;149(4):518-28.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
产品手册
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